For all who need to comply with REACH directives and assess chemical risks

This practice-oriented training intends to

• explain the REACH regulatory framework,
• become familiar with the modelling tools,
• provide an approach on how to select an appropriate tool for a given set of exposure conditions,
• better interpret results generated by exposure assessment models.

9 November 2020, 16:00 CET, via Zoom

Hildegard Doerenkamp, a lifelong animal lover, was active in supporting alternatives to animal testing since she first saw a televised interview with toxicology Professor Gerhard Zbinden in 1982. They combined their individual assets to form the Doerenkamp-Zbinden Foundation to support the 3Rs of alternatives (Reduction, Refinement, and Replacement) ...

Speakers: Franz Gruber (President, Doerenkamp-Zbinden Foundation), Marcel Leist (Konstanz), Thomas Hartung (Baltimore), Bass Blaauboer (Utrecht), Pierre Cosson (Geneva), Akbarsha Mohammad Abdulkader (Mahatma Gandhi-Doerenkamp Center, India).

The TEDD Annual Meeting 2020 is dedicated to cutting edge academic and industrial research. We focus on microphysiological systems (MPS) and its application in different fields, including research on the COVID-19 and the development of in vitro disease and infection models. The on-line event will not only provide presentations but also allow you to network. Each participant has an opportunity to matchmake and request virtual 1-1 meetings. Additionally, we provide the exhibitors with the possibility to present their services and take part in virtual exhibition sessions over the “lunch break”.

4 sessions sont prévues :
Session I : Perturbateurs neuroendocriniens et métaboliques : Où en est-on ?
Session II : Modèles d’études et risques de biais
Session III : Risques émergents & nouvelles approches
Session IV : Les PE dans les Projets européens

The Webinar aims to share experience and lessons learned from providing training in the field of chemical risk assessment and to inspire and support trainers including new trainers.

EPA will host its Second Annual Conference on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing virtually.

Agenda topics

• Implementation of Animal Testing Reduction at EPA
• State of the Science in Development of NAMs (Case Studies)
• Addressing Current Limitations in NAMs
• Developing Scientific Confidence in NAMs

When:  Thursday, October 8, 2020 @ 12pm EDT
Presenter:  Dr. Mel Andersen

Differential gene expression analysis (DEGA) has proved useful for assessing modes of action (MOAs) with various compounds both following in life exposures to intact animals and with in vitro exposures of cells in culture. Various tools have been developed over the past decade or so to assist in the analysis of these patterns of differential gene expression, including heatmaps, pathway enrichment analysis, benchmark dose estimations and network representations of affected pathways using different ontologies. MOAs inferred from using these gene expression results have sometimes confirmed expectations from conventional toxicity testing and sometimes proved divergent, giving a more comprehensive look at the affected biology with compounds such as styrene, dichloromethane and vanadium pentoxide. In this webinar we discuss modes of action inferred from gene expression studies in relation to dose response modeling, dose-dependent transitions, pathway perturbations and comparing results from one treatment condition with another. The application of these DEGA tools to both in vivo and in vitro patterns of gene expression will likely uncover subtle differences in response among even similar compounds and also provide new tools for assessing the biological consequences of exposures to bioactive compounds. Toxicologists and risk assessors need to be prepared for surprises as these new biological tools are applied to assess MOA even for well-studied compounds.

The objective of the workshop will be to foster knowledge exchange, networking, and discussions on the concept of the application of the AOP programme to the radiation community. Experts from chemical toxicology will provide experiences on the framework through interactive discussions. The workshop will introduce the AOP concept, how it is being used in other disciplines and areas where it can support the radiation community.

The scientific program consists of 13 topic sessions chaired by renowned colleagues in the field. Each of these sessions is arranged to encourage questions and exchanges between presenters and participants. Thanks to the international scientific committee, that developed the program, there will be the opportunity to discover the most remarkable innovations from all over the world, from fundamentals in microfluidics including cells on a chip to the most recent advances in instrumentation or couplings with CE or LC; from sample preparation and clinical applications to «omics».

At this one-day symposium we would like to paint a picture of the status quo on pesticide exposure and hazard assessment by inviting the leading Swiss experts from the research, regulatory and industry communities. In light of the upcoming popular initiatives aiming to restrict or ban the use of synthetic pesticides, what is the current state of the evidence on the health hazards of pesticides? Considering the public concern with pesticides, we would further like to give some insight into the perspectives of risk perception, communication and management. Finally, we would like to discuss how published research (in vitro, in vivo, epidemiology) on potential adverse health effects of marketed pesticides can have a regulatory impact.

See programme for further information.