This virtual meeting will include a perspective by Tatyana Doktorova (Edelweiss Connect) followed by a short discussion session. 

The Adverse Outcome Pathway is a framework which describes the initial interaction of a stressor with a biomolecule and continuing with dependent series of intermediate key events (KEs) at different levels of biological organization, while finally ending in an adverse outcome (AOP). The primary objective for the introduction of the AOP concept was knowledge assembly, specifically, making information attained through scientific research by subject-matter experts and distributed in the body of scientific literature accessible to regulators during the decision-making process. It was then quickly recognized as a tool to enhance communication between scientists involved in generating biological/toxicological data and the potential end users of this information, such as modelers or risk assessors. In this session, we would like to provide an update of the current advances of scientists in the area as exemplified by case studies.

Vorträge in Deutsch, Französisch und Englisch / Conférence en allemand, français et anglais.

When: Wednesday 15 January 2020, 1 pm (CET)

This second webinar on Adverse Outcome Pathways (AOPs) will focus on the importance of weight of evidence in the process of developing AOPs, the types and lines of evidences assembled, examples demonstrating the lines of evidence and understanding why quantitative AOPs are developed. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment.

Presentations by: Magda Sachana (OECD), Bette Meek (Ottawa), Kristie Sullivan (PCRM), Dan Villeneuve (US EPA)

This virtual meeting will include a perspective by Daniel Burgwinkel (KRM Competence Center) followed by a short discussion session.

Cloud-based platforms speed up the process of developing products and open new opportunities for Safety Assessments and the collaboration between research partners and regulators. One the other hand concerns about cyber-security, tampered data integrity and reproducibility issues arise. The talk gives an overview of the challenges of data integrity, data provenance and reproducibility and proposes a set of principles and best practices that can be applied in addition to the FAIR principles of the research community (findability, accessibility, interoperability and reuse of digital assets).

This year's Annual Meeting of the Swiss Society of Toxicology will be held in conjunction with a celebration of the 10th Anniversary of the Swiss Centre for Applied Human Toxicology (SCAHT). Attractive lectures and sessions with well-balanced inputs from academia, industry and regulators will be offered. Beside the scientific presentations there will be various networking opportunities.

Speakers will share examples of introductory training courses in chemical risk assessment, including learning outcomes, content, learning activities, examinations, training material, and case studies.

Registration is required to join this event.

At this 2 days training, experts will put emphasis on sensitization models and skin sensitization quantitative risk assessment. Introduction and application of validated methods (DPRA, LuSens), a coculture model (COCAT), in silico intergrating tools and their application in risk assessment will be demonstrated. The training will focus on data assessment, testing strategies and their use in skin sensitization quantitative risk assessment.

This two days hands-on training will cover practical use of respiratory in vitro 3D tissues and exposure devices to evaluate acute and repeated dose inhalation toxicity. To mimic systemic context, interconnection strategies of lung tissues will be presented.

The course is a two-day laboratory workshop in Leiden. This training instructs the attendee in best practices procedures for in silico and in vitro assays related to acute and chronic cardiotoxicity.