This course provides a broad overview on the organ systems of interest as well as standard tests to investigate drug effects on these systems. Each organ system will be introduced before detailed information on the safety pharmacology aspects is provided. Integration of Safety Pharmacology findings in an overall risk assessment will be demonstrated. Concordance data and case reports will provide the evidence how meaningful pre-clinical data are for the clinical situation. The course is part of DGPT Modular Training Programme in Toxicology ("Fachtoxikologe/in DGPT") and the registration has to be made via the German Society of Toxicology.

 

Die als Blockkurs von zwei Tagen konzipierte Lehrveranstaltung über Gifttiere beinhaltet folgende Schwerpunkte: Biologie, Vorkommen und Lebensweise aller medizinisch relevanten Gifttiergruppen Struktur und Funktionsweise von Giftapparaten Zusammensetzung, Chemie und Pharmakologie von Tiergiften Prävention von Gifttierunfällen Erste Hilfe bei Gifttierunfällen Weitere Informationen finden Sie hier.

Beyond two main topics, presentations on actual and relevant topics from the different disciplines of toxicology and safety sciences will be provided.

The theme for the 23rd SETAC Europe LCA Case Study Symposium is Life Cycle Assessment for Decision Support. The focus of these two days is on case studies that highlight both solutions and challenges when applying consequential modelling for comparisons of products, projects, and strategies. The various sessions of the scientific programme cover all aspects of the application of LCA to decision making in business practice, environmental product declarations, due diligence, social responsibility, environmental management, and policy development.

The topics of the conference are: defined approaches towards regulatory acceptance, simulations of exposure and transport, integration and interoperability: software, integration and interoperability: data, high-content imaging and characterization of experimental conditions. Including session "Defined Approaches Towards Regulatory Acceptance" chaired by Prof. Martin Wilks, SCAHT, and "High-Content Imaging" chaired by Prof. Bob van der Water, Leiden, coordinator of EUToxRisk. Further information.

The event starts on the evening of 15 November 2017 with a poster presentation and networking session. On 16 November, a plenary session will be dedicated to LRI projects impact with focus on environmental and human health questions, including non-extractable residues, ecosystems services, chemical activity, biodegradation, bioaccumulation, carcinogenicity and inhalation nanotoxicology. This will be followed by a thematic session on: “Making sense of Omics for regulatory applications”. 

Leading scientists from across the world will take part in the colloquium to explore future directions for evidence integration in human risk assessment of chemicals.

In Part-2, more emphasis will be put on skin sensitization models such as h-clat (OECD TG 442E), DPRA (OECD TG 442C) or LuSens. The participants will also perform the IL/18 epiderm for identification and classification of skin sensitizing chemicals (MatTek) as well as the GARD skin sensitization test that detects potency (Senzagen).

In light of the limitations of existing non-animal based hazard assessment methodologies, particularly in the area of repeated dose as well as developmental and reproductive toxicity, readacross is currently considered to be the most applicable strategy in support of chemical’s hazard assessment. In this context, in silico tools play a critical role in identifying and justifying analogues suitable for the assessment of chemicals for which hazard data are lacking. This training co-organised with Toxminds is designed to give the necessary background along with tailored case studies to provide hands-on experience how in silico tools can be used in supporting a chemical’s hazard assessments: for example as stand-alone tools or for the identification and justification of analogues for use in read-across.